Igi 1 f11 f12 free download3/9/2024 ![]() Despite the important regulatory role of proteases, knowledge of their inhibitors remains largely incomplete with the vast majority of proteases lacking an annotated inhibitor. Proteases generate thousands of proteoforms that dynamically shape the functional state of proteomes. Here, we investigated computational methods in the prediction of a specific type of interaction, the inhibitory interactions between proteases and their inhibitors. Whereas computational predictions can guide biochemical experiments, low validation rates of predictions remain a major limitation. Identification of protein interactions is a major goal in molecular biology, but biochemical methods, although improving, remain limited in coverage and accuracy. Protein interactions shape proteome function and thus biology.
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